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Somatostatin Receptors (SSTRs)

Are receptors for a small neuropeptide associated with neural signaling. They can play a key role in the diagnosis and treatment of neuroendocrine tumors (NETs).

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SSTR2

A Somatostatin Receptor Protein on a tumor cell which can act as a target for certain Neuroendocrine Cancer drugs. See also: Receptor Positive

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SUV (Standard Uptake Value)

A marker protein for neuroendocrine tumors.

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Targeted Alpha Therapy (TAT)

An emerging radiopharmaceutical therapy utilizing alpha particle emitters. The short range emission of alpha particle energy is expected to provide greater localized efficacy killing cancer cells while reducing toxic effects to surrounding heathy tissue. See Also: Alpha Particles

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Theranostics

Line of treatments which combine one radioactive drug to diagnose and a second radioactive drug delivered to primary and metastasis tumors for treatment.

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XERMELO (Telotristat Ethyl)

Brand name for a prescription drug used to inhibit carcinoid syndrome diarrhea not satisfactorily controlled by SSAs. Also prescribed to control the overproduction of serotonin.

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18F-dihydroxy-phenylalanine

A radioactive substance or tracer that is used in a PET scan to detect the location of NETs. Also called flurodopa or 18F-DOPA.

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Ablation

The destruction or removal of a body part, like a part of an organ, a growth, or some internal structure. Ablation can be done with surgery, heat, radio waves, hormones, or drugs.

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Adrenal Gland

A gland near the top of the kidney that creates hormones, like adrenaline and cortisol. Your body has 2 adrenal glands.

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Adrenaline

A hormone and neurotransmitter. Also called epinephrine.

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Adverse Events

Another name for side effects.

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Adrenocorticotropic Hormone (ACTH)

A hormone also known as corticotrophin. It is produced by the anterior pituitary gland.

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Endocrine Cells

Cells that help regulate various body functions, such as growth, reproduction and metabolism. There are three types of endocrine cells; alpha cells which secrete glucagon, beta cells which secrete insulin, and delta cells which suppress the secretion of glucagon and insulin.

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Epidemiology

Medical speciality that investigates the factors which determine the presence or absence of a disease, plus it’s incidence and it’s prevalence.

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AFINITOR (Everolimus)

Oral chemotherapy indicated for the treatment of adult patients with advanced or high grade Neuroendocrine Tumors.

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Aggressive

A term used to describe the speed or extent to which a tumor grows and spreads.

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Angiogram

A type of diagnostic imaging that uses X-rays enhanced with a radiographic contrast medium.

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Atypical Carcinoid

Term sometimes used for a kind of neuroendocrine tumor (NET) in the lungs. A lung NET described as an atypical carcinoid tends to be faster growing than a typical carcinoid, but is not as aggressive as a high-grade lung NET.

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Benign Tumor

A noncancerous growth that does not invade nearby tissue or spread from one part of the body to another.

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Biomarker

A substance that can be found in the blood or in the body that is associated with the presence of disease. In cancers, specific biomarkers can point to the presence of specific cancers. With names like CA 125 (which can indicate ovarian cancer) and CEA (which can mean lung, ovarian, breast, pancreatic, or digestive tract tumors), biomarkers are also called tumor markers. Some biomarkers related to carcinoid tumors are CgA and Ki-67

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